Global miR profiling study revealed that miR-143 and miR-145 were upregulated in RA-FLSs of human patients compared to osteoarthritis fibroblast-like synoviocytes (OA-FLSs) and were highly expressed in RA-FLSs, and this change in expression affected the TNF-α pathway. The gene discussed is TNF; the disease is rheumatoid arthritis.