ZSCAN22 is a zinc finger and SCAN domain TF that helps maintain cellular homeostasis by regulating genes involved in proliferation, differentiation, and apoptosis [143]; genetic and epigenetic alterations disrupting its function can impair critical pathways like cell cycle and DNA repair, contributing to tumor progression [144], while non-coding RNAs further modulate its expression in complex regulatory networks [145]. The gene discussed is TF; the disease is neoplasm.