IGHE and hyper-IgE syndrome: Emerging evidence links immune-mediated diseases, including systemic lupus erythematosus [11], rheumatoid arthritis [12], anti-phospholipid syndrome [10], Hashimoto’s disease [13], thyroid dysfunction [14], and allergic inflammation [9], to inner ear pathology, raising the hypothesis that dysregulated IgE in hyper-IgE syndrome could contribute to audiovestibular impairment [15].