In a previous report by and the colleagues [22], the authors demonstrated that the cutoff point of IgE (i.e., total IgE: 177.42 IU/mL, specific IgE 3.53 IU/mL) could serve as an indicator of transformation of Ménière’s disease and the initiation of sensorineural hearing loss. This evidence concerns the gene IGHE and Meniere disease.