The interaction between the COLEC11 (rs7567833G>A) and MASP2 (g.1961795C>A, p. D371Y) polymorphisms is thought to behave synergistically in reaction to the parasite that causes Chagas disease, Trypanosoma cruzi, and this enhanced complement response subsequently contributes to cardiomyopathy [61]. The gene discussed is MASP2; the disease is Chagas disease.