To further assess cytokine production capacity in relation to the rs4728141 SNP, IL-1β, IL-1Ra, and IL-6 concentrations were measured in cell culture supernatants of 24 h stimulated PBMCs in normouricemic controls and gout patients after stimulations with palmitate and palmitate in combination with MSU crystals (n = 135 and 93), LPS (n = 141 and 101), E. coli (n = 153 and 110), S. aureus (n = 153 and 109), M. tuberculosis lysate (n = 153 and 110), B. burgdorferi (n = 144 and 108), and C. albicans (n = 153 and 110). This evidence concerns the gene IL1B and gout.