Additionally, the interaction of PDCD1 on T cells binding with PD-L1 on tumor cells enables the evasion of tumor cell recognition by T cells [24], Tumor necrosis factor (TNF) inhibits tumor cell growth [25], and CD28 mediates co-stimulation of T cells, enhancing their survival, proliferation, and cytokine production [26]. This evidence concerns the gene CD28 and neoplasm.