NOS2 and hypertensive disorder: Another study based on mouse models of salt-sensitive HTN, obtained by inhibiting iNOS to test the relevance of immune reactivity driven by HSP70 in HTN, induced immune tolerance through the peritoneal infusion of HSP70, achieving a regulatory response of T cells, correcting the immune activity of HSP70, reducing the infiltration of immune cells in the kidney tissue, and preventing HTA caused by a high-salt diet [56].