Recent data have shown a strong association between HTN and the inflammatory response, where various stimuli—including Ang II and sodium, to name a few—are capable of inducing a response from the immune system (SI) by initiating a signaling cascade that leads to the expression of pro-inflammatory genes with the subsequent production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IFN-g, and IL-17A) and the activation of adaptive immunity. Here, TNF is linked to hypertensive disorder.