TNF and hypertensive disorder: For example, a study described that eight patients with essential HTN who received MMF for coexisting rheumatoid arthritis or psoriasis without modifying their antihypertensive treatment or diet had a decrease in BP during the MMF treatment associated with a reduction in urinary TNF-α, highlighting that the BP returned to previously high levels when MMF was discontinued [137], suggesting that the improvement in HTN was the result of immunosuppression.