Supporting this rationale, margatoxin (MgTx), another Kv1.3 inhibitor from C. margaritatus, has demonstrated both in vitro and in vivo efficacy against A549 human lung adenocarcinoma, where it suppressed tumor cell proliferation, modulated cell-cycle regulators, and significantly reduced tumor growth in xenograft models [61]. The gene discussed is KCNA3; the disease is neoplasm.