Compared to inv(16) AML, t(8;21) AML is characterized by a higher prevalence of mutations in genes that regulate chromatin structure, such as ASXL1 and ASXL2 (Additional Sex Combs-Like 2), or genes that encode components of the cohesin complex, like RAD21 (Radiation Sensitive 21) and SMC1A (Structural Maintenance of Chromosomes 1A) [79]. Here, ASXL1 is linked to acute myeloid leukemia.