RUNX1 and Down syndrome: CBFA2T3::GLIS2 (Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To 3::GLI-Similar 2) results from inv(16)(p13.3q24.3) and is characteristic of non-Down syndrome acute megakaryoblastic leukemia (AMKL) (M7 Fab); it is distinct from CBF-AML.