IR usually precedes the diagnosis of T2DM by at least 10 years [8,9,10,11], with the decreased insulin sensitivity being associated with hyperglycemia, hyperuricemia, dyslipidemia, hypertension, endothelial dysfunction, and increased inflammatory markers, as well as the prothrombotic state, all of which lead to metabolic syndrome, T2DM, and metabolic dysfunction-associated steatotic liver disease (MASLD) [12,13,14]. This evidence concerns the gene INS and metabolic syndrome.