Tumor cells exploit this plasticity by manipulating immune cell subsets including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages, dendritic cells, and regulatory T cells (Tregs) as well as soluble mediators such as vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and cytokines like IL-10. The gene discussed is VEGFA; the disease is neoplasm.