TARDBP and amyotrophic lateral sclerosis: In ALS-relevant cellular systems, these compounds have been shown to restore nuclear TDP-43 and FUS localization, reversing pathological cytoplasmic aggregation; to augment antioxidant gene expression, reinforcing redox homeostasis; and to promote clearance of aberrant RNA granules and RBP inclusions, alleviating proteotoxic stress [125,126,127].