NFE2L2 and amyotrophic lateral sclerosis: Unlike antisense oligonucleotides (ASOs) or siRNAs, which selectively target individual transcripts, Nrf2 activation offers a systems-level strategy that modulates multiple intersecting domains of ALS pathogenesis, including oxidative stress, RBP dynamics, SG behavior, nucleocytoplasmic transport, and RNA surveillance [40,102,103].