In ALS models, including zebrafish expressing mutant TDP-43 and rodent SOD1G93A lines M102 has recently been used to improve motor neuron viability, to reduce cytoplasmic stress granule burden, to restore mitochondrial membrane potential and bioenergetic function, and to delay neuromuscular degeneration and extend functional lifespan [124]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.