Transcriptomic profiling of Nrf2-activated ALS patient-derived motor neurons identified significant modulation of RNA-binding proteins implicated in ALS, including TDP-43, Heterogeneous nuclear ribonucleoprotein1 (hnRNPA1), and FUS, alongside altered expression of genes controlling nucleocytoplasmic transport and stress granule assembly [28,35]. Here, HNRNPA1 is linked to amyotrophic lateral sclerosis.