Emerging transcriptomic and proteomic data from ALS-relevant iPSC-derived astrocytes and motor neurons demonstrate that activation of Nrf2 leads to altered expression of key disease-associated RBPs, including hnRNPA1, FUS, and T-cell-restricted intracellular antigen 1, which are essential for mRNA splicing, axonal transport, stress granule dynamics, and RNA stability, respectively [90]. Here, HNRNPA1 is linked to amyotrophic lateral sclerosis.