Conversely, other studies have reported lower counts of the following immune cells in patients with obesity and/or MS compared to their lean counterparts: a decreased percentage of total lymphocytes [69], CD4+CD45RA+ [91], CD8+CD45RA+, and B cells (% and cells/μL) [68,75]. The gene discussed is CD8A; the disease is obesity due to melanocortin 4 receptor deficiency.