Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that the core targets of BHBE in the treatment of T2DM were enriched in 177 signaling pathways, with the most significant pathways including the PI3K/AKT pathway, lipid and atherosclerosis pathway, MAPK signaling pathway, AGE-RAGE signaling pathway in diabetic complications, and metabolic pathways (Figure 3E and Supplementary Table S7). Here, RENBP is linked to atherosclerosis.