In a recent preprint 3-hydroxybutyrate dehydrogenase 2 (BDH2) protein, a dehydrogenase/reductase family member, was suggested to be a key effector in organelles Fe2+ redistribution, localizing at the mitochondria–lysosome contacts, transferring iron that endorses mitochondrial OXPHOS and ATP production which is then utilized by lysosomes to maintain a low pH through the activity of V-ATPase for lysosomal acidification in melanoma cell lines. Here, BDH2 is linked to melanoma.