In addition, in an in vivo study using immunocompromised athymic nude mice bearing HCT116 cells xenograft tumors, purified p28-p53 (Figure 1D and Figure S5), but not p28-GFP (Figure 1D and Figure S5) or p53 without CPP (Figure S6), exhibited potent inhibition of xenograft tumor growth. This evidence concerns the gene TP53 and neoplasm.