This designed protein, CEABP1, was fused to p53 tagged with p28, a CPP derived from Pseudomonas aeruginosa [51,52,53,54], to specifically deliver purified p53 protein into CRC cells through endocytosis to stimulate the expression of p53 target genes, promote cell cycle arrest and apoptosis, and prevent CRC cell growth. The gene discussed is TP53; the disease is colorectal carcinoma.