CDH17 also mediates integrin signalling: Casal et al. showed that CDH17 binds to α2β1 integrin via its Arginylglycylaspartic acid (RGD) motif, activating integrin-dependent adhesion, Extracellular signal-Regulated Kinase (ERK1/2) pathway, and Focal Adhesion Kinase (FAK) signalling to promote tumour growth and metastasis. This evidence concerns the gene CDH17 and neoplasm.