It assumes that cytokine release is mediated by macrophage activation, driven by three main mechanisms: the release of inflammatory mediators by activated CAR-T cells, the release of DAMPs (Damage-Associated Molecular Patterns, which are molecules released by stressed or dying cells that trigger immune activation) from tumour cell death, and contact-dependent activation between macrophages and CAR-T cells via CD40/CD40–ligand interaction. This evidence concerns the gene CD40 and neoplasm.