By upregulating adhesion-related genes such as COL1A1, fibronectin (FN), ITGA2, and ITGB1 and activating the focal adhesion kinase (FAK) signaling pathway, it reinforced the stability of the cell–material interface, contributing to the formation of a soft tissue seal and reducing the risk of peri-implantitis [184]. The gene discussed is FN1; the disease is Peri-Implantitis.