Targeting circulating merozoites and pRBCs, TH2 CD4 cells stimulate B cells to generate antibodies, particularly immunoglobulin G, which sets off a series of events. Control the inflammatory reaction. both antibody-mediated and cell-mediated immunity.By assisting macrophages in eliminating parasitized red blood cells, Th1 AIDS macrophages support cell-mediated immunity.Produce cytokines such as interferon gamma, enhancing CD8+ function. The gene discussed is CD8A; the disease is AIDS.