SCN8A and scoliosis: Among the candidate genes (DSCAM, SCN8A, LOC121820349, TRNAC-GCA-141, LOC114117597, and STK35) associated with BLH in Tianmu polytocous sheep, the DSCAM gene has been reported to cause skeletal growth abnormalities (e.g., scoliosis) in humans when mutated [57,58], which could similarly influence BLH in livestock.