In vivo, in LSL-KrasG12D; Trp53flox/flox (KP) mice, endothelial HSPB1 knockdown via shRNA increased α-SMA+/CD31+ partial EndMT cells, and around tumor vessels, collagen deposition and expression of TGF-β1 and FSP1 were elevated. The gene discussed is S100A4; the disease is neoplasm.