Unlike p53, endothelial TGFBR2 knockdown promoted EndMT: in EC-TGFBR2KD (Tie2-Cre;Tgfbr2flox/+) mice bearing tumors, irradiation led to greater tumor size and more metastatic nodules than in wild type, along with increased fractions of α-SMA+/CD31+ EndMT vessels and α-SMA+NG2+ pericytes. The gene discussed is TEK; the disease is neoplasm.