Ciszewski et al. (2017) [30] used CM from colorectal cancer cell lines (LS180, LoVo, and SNAI1-overexpressing LS180-SNAIL) to show that greater tumor invasiveness was associated with EndMT features in HMEC-1: increased cell length (spindle-like morphology), stress-fiber remodeling, decreased endothelial markers (claudin, ZO-1), and increased mesenchymal markers (α-SMA, FSP1, N-cadherin) at the protein level, thereby demonstrating CM-induced EndMT. This evidence concerns the gene S100A4 and neoplasm.