Another study reported the regulation of the key oncogene c-MYC by PRMT3; Hu et al. revealed that PRMT3 inhibits the polyubiquitination of c-MYC, leading to increased stability of c-MYC in CRC cells, thereby promoting the c-MYC-dependent proliferation of CRC cells in vitro and in vivo [61]. The gene discussed is PRMT3; the disease is colorectal carcinoma.