Recent preclinical studies have also highlighted its involvement in CNS repair: for example, Matei et al. demonstrated that intranasal Wnt3a administration upregulated FoxM1 via the Frizzled-1/PIWI1a axis and reduced infarct volume following stroke, while Jia et al. reported that FoxM1 modulates a miRNA network governing neural stem cell homeostasis [33,37]. This evidence concerns the gene FZD1 and Stroke.