In addition, autophagy–lysosome dysfunction is an important pathogenic process in PD, and mutations in leucine-rich repeat kinase 2 (LRRK2), GBA, and ATPase Type 13A2 (ATP13A2) illustrate how genetic dysregulation of lysosomal biology facilitates neurodegeneration [25,26]. The gene discussed is ATP13A2; the disease is Parkinson disease.