Meta-analyses report that high Glucose-Transporter-1 (GLUT1) expression (a hypoxia/glycolysis marker) correlates with inferior overall survival across cancers; Carbonic Anhydrase IX (CAIX), an established hypoxia-induced pH regulator, is likewise associated with adverse prognosis in many solid tumors (with some tumor-specific exceptions) [95]. This evidence concerns the gene CA9 and cancer.