Together, these data position oxidative stress as well as sulfur and iron biochemistry (in particular, TfR1, CBS, CDO1, CTH, MPST, TST, p53) as interconnected determinants of glioma behavior and as rational foundations for studies probing how selective manipulation of ROS, sulfane sulfur signaling, and iron transport can be leveraged to constrain invasion, re-sensitize tumors, and improve outcomes. This evidence concerns the gene CDO1 and central nervous system cancer.