By 2009, ZC3H12A (also termed MCPIP1 or Regnase-1) was established as a ribonuclease that binds to the 3′ UTR of target mRNAs via its CCCH zinc finger domain and cleaves transcripts encoding inflammatory mediators, thereby playing an essential role in preventing autoimmunity diseases and regulating inflammation [15]. The gene discussed is ZC3H12A; the disease is autoimmune disease.