CD4 and gastric cancer: Similarly, in gastric cancer (GC), dysregulation of the linc00936/miR-425-3p/ZC3H12A axis similarly suppresses the antitumor immunity of CIK cells and CD4+ T cells by promoting the secretion of immunosuppressive factors such as VEGF, IL-10, and TGF-β1, ultimately leading to immune escape and disease progression [76].