Allergic rhinitis (AR), an immunoglobulin E (IgE)-mediated inflammation of the nasal mucosa induced by inhaled allergens to which a patient is sensitized, is characterized by various symptoms, including repeated sneezing, nose itching, nasal obstruction, rhinorrhea, and ocular symptoms, involving inflammation of nasal mucosa [52] (Figure 2). This evidence concerns the gene IGHE and allergic rhinitis.