RASA1 and cardiac hypertrophy: Additionally, the sponging activity of circHRCR against miR-223 plays a role in regulating cardiac hypertrophy by preventing the downregulation of anti-hypertrophic genes, such as FBXW7 and RASA1, attenuating the pathological growth of cardiomyocytes, and acting as a therapeutic target for cardiac hypertrophy [30,35].