EML4 and non-small cell lung carcinoma: For example, in lung cancer research, it has been demonstrated that silencing SIRT1 regulates autophagy in non-small cell lung cancer cells with EML4-ALK L1196M and EML4-ALK G1202R mutations through the AMPK/mTOR/S6K signaling pathway, thereby promoting Epithelial–Mesenchymal Transition (EMT) and resistance to crizotinib [54].