Research on SIRT4 and SIRT5 in AKI is still limited, with studies indicating that SIRT5 may mitigate AKI [84,85,86], possibly by regulating the Nuclear factor erythroid 2-related factor 2/Heme oxygenase 1 (Nrf2/HO-1) pathway [86]. This evidence concerns the gene NFE2L2 and acute kidney injury.