INHBE and familial pancreatic carcinoma: In terms of the activin–inhibin signaling pathway, the CAGE analysis after 6 h of PFOA treatment showed increased gene expression of activin and inhibin A. Regarding the relationship between activin and cancer, Mancinelli et al. [49] reported evidence indicating that activin A signaling is important in several cancers, including CRC [50,51,52] and mammary [53], lung [54], esophageal [55], and pancreatic cancers [56].