In silico analysis shows the hsa-miR-4717-5p and hsa-miR-22-3p (biomarker of adverse events in HF) as strongly validated targets of RGS2 and a connection between hsa-miR-22-3p and miR-132 via SIRT1 (Supplementary Figure S6B). The gene discussed is SIRT1; the disease is hydrops fetalis.