Polymorphisms on these receptors (e.g., P2RY1 polymorphism SNPs rs106577, rs701265—also known as 1622A/G mutation, P2RY12 SNP rs9859538, rs7615865) were associated with different platelet reactivity and inadequate Aspirin responsivity in CAD [77,78]. This evidence concerns the gene P2RY12 and coronary artery disorder.