For instance, mutations in NEK1 have now been implicated in amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), hereditary spastic paraplegia (HSP), and cerebellar ataxia, underscoring its multifaceted role in neuronal homeostasis [9,62,95,96,97,98]. The gene discussed is NEK1; the disease is aceruloplasminemia.