NEK8 and cancer: For instance, overexpression of NEK8 in several cancer cell lines, including U2OS osteosarcoma, HepG2 hepatocarcinoma, Sk-Hep-1 endothelial, and MCF-7 breast cancer cells, suggests a role in tumorigenesis, where its involvement in replication stress response and DNA repair pathways may aid cancer cell survival and proliferation [165,169,170,171].