To investigate the possible role of PSCA in neuroinflammation, which is often observed in neurological diseases [68,69,70,71,72], we assayed the influence of ws-PSCA on secretion of various inflammatory factors (ALCAM-1, L-selectin, TNFα, TNFβ, IL10, and IL12 p 40) and adhesion molecules (ICAM-1, PSGL-1, VCAM-1, EpCAM, E-selectin) by the primary neurons and astrocytes. Here, VCAM1 is linked to nervous system disorder.