Contrarily to PSCA, Lynx1 is downregulated in AD [132], and incubation with ws-Lynx1 stimulates astrocytes to secrete the dendritic growth factor ALCAM-1 and abolishes the secretion of pro-inflammatory factors ICAM-1, PSGL-1, VCAM-1, CD44, and NCAM-1 [37]. This evidence concerns the gene VCAM1 and Alzheimer disease.