SCAR/mc-COX2 (Steatohepatitis-associated circRNA ATP5B regulator/mt-circ-COX2), which is produced from the COX2 locus on the L-strand, is downregulated in liver fibroblasts from patients with nonalcoholic steatohepatitis (NASH) and upregulated in plasma exosomes of chronic lymphocytic leukemia (CLL) patients [137]. This evidence concerns the gene ATP5F1B and metabolic dysfunction-associated steatohepatitis.