STAT3 and colorectal carcinoma: PKM2 was significantly upregulated in CRC tissues as IHC staining and Western blot analyses reveal its predominant localization in the cytoplasm and nucleus, where it influences metabolic reprogramming and oncogenic signaling pathways, such as STAT3, β-catenin, and HIF-1α [123,124,125,126,127,128,129].