Riedinger et al. identified somatic mutations c.1165C > T (p.Arg389Ter), c.2246A > C (p.Glu749Ala), c.2168C > T (p.Ser723Phe), and c.1007del (p.Pro336fs) of MSH2 in two cases of EEC and identified the somatic mutation c.2011A > G (p.Asn671Asp) of MSH2 in one case of USC [50]. The gene discussed is MSH2; the disease is exstrophy-epispadias complex.