Korhonen et al. conducted a pioneering evaluation of the pathogenicity of seven MLH3 germline mutations—including c.1939 C > T, c.2449 A > G, c.4351 G > A, and c.3826 T > C—identified in patients with CRC or EC, without differentiating between pathological types. The gene discussed is MLH3; the disease is colorectal carcinoma.