While these factors are known to mediate pro-angiogenic and tumor-promoting processes in the TME (e.g., IL-6 and IL-8 can upregulate VEGFA expression in tumor cells to drive angiogenesis) [86], analysis of 22Rv1 tumor cells under huB12-MMAE treatment showed no change in VEGFA expression. The gene discussed is CXCL8; the disease is neoplasm.