EDN1 and glaucoma: Luminex analysis of AqH samples revealed significantly elevated levels of MMP-2, MMP-3, ET-1, sEMMPRIN, ZAG, sLOX-1, follistatin, cortisol, endostatin, sTIE-2, and PDGF-BB in glaucoma participants (adjusted p < 0.05) (Figure 1B; Supplementary Figure S1; Supplementary Table S3).