The relationship between NOX2 and sCD40L was further studied in patients with X-CGD compared with carriers of hereditary deficiency of NOX2, obese women (who express higher levels of NOX2), and healthy subjects, aiming to compare sCD40L levels in different groups with different degrees of NOX2 activation: the results confirmed reduced plasma levels of sCD40L in X-CGD patients and in X-CGD carriers, compared with healthy subjects; moreover, obese women showed higher levels of sCD40L than controls [40]. Here, CYBB is linked to chronic granulomatous disease.