CYBB and hyperinsulinemic hypoglycemia, familial, 4: Its physiological role is linked to bacterial killing in phagocytes through production of radical oxygen species (ROS), but NOX2 is also involved in platelet activation via superoxide anion formation and conversion to H2O2 [12,13]: experimental data show that ROS influence platelet recruitment and thrombus growth, and, conversely, that in patients with genetically determined NOX2 deficiency, platelet activation is impaired and carotid atherosclerotic burden is reduced [13].