ACTA1 and Hepatic fibrosis: The massive production and activation of myofibroblasts (MFBs)—which secrete components including collagen, α-smooth muscle actin (α-SMA), and tissue inhibitor of metalloproteinases 1 (TIMP1) [114,115]-are critical to the progression of liver fibrosis, and MFBs mainly originate from the activation of HSCs.