Previous studies using PBM in microglia have reported modulatory effects on inflammatory pathways: Vogel et al. [11] demonstrated that low-level PBM reduced Iba-1 expression and pro-inflammatory cytokines in an in vivo ischemic stroke model, while Chen et al. [12] showed that 1070 nm PBM polarized BV-2 microglia toward an anti-inflammatory phenotype (M2), reducing pro-inflammatory mediators and enhancing neuroprotective signaling. This evidence concerns the gene AIF1 and ischemic stroke.