PPARGC1A and congenital rubella syndrome: Interestingly, 10 days after NX, heart tissues from the NX group did not show a reduction in mitochondrial biogenesis factors or OXPHOS subunit protein levels (Supplementary Figure S1), suggesting that in heart tissues, bioenergetic alterations (Figure 6, Figure 7 and Figure 8) are not yet associated with impairments in SIRT/PGC-1α/NRFs, as seen in other CRS models at more advanced stages [1,25].