As far as the neuroprotective effect of FA in AD is concerned, studies conducted by Allan Butterfield group reported that FAEE (25 μM or 150 mg/kg intraperitoneal) prevented Aβ(1-42)-induced cytotoxicity, ROS generation, protein and lipid oxidation, and induction of inducible nitric oxide synthase in rat cortical neuronal cultures and gerbil brain synaptosomes [169,170]. This evidence concerns the gene NOS2 and Alzheimer disease.