In other contexts, erianin activates ROS-mediated apoptosis and inhibits JAK/STAT signaling in esophageal carcinoma [45], while in pancreatic cancer it modulates the AKT/FOXO1 and ASK1/JNK/p38 MAPK pathways to suppress proliferation and migration [8]. Here, MAP3K5 is linked to familial pancreatic carcinoma.