In other contexts, erianin activates ROS-mediated apoptosis and inhibits JAK/STAT signaling in esophageal carcinoma [45], while in pancreatic cancer it modulates the AKT/FOXO1 and ASK1/JNK/p38 MAPK pathways to suppress proliferation and migration [8]. Here, MAPK8 is linked to pancreatic neoplasm.