Given that the antioxidant regulator NRF2 is intricately linked with NF-κB [16], a pivotal transcriptional regulator of stress-responsive genes, we postulate that NBCn1 functions as a key ion transporter whose expression and/or activity is modulated by NF-κB signaling during oxidative stress in lung cancer cells. This evidence concerns the gene SLC4A7 and lung cancer.