Given that the antioxidant regulator NRF2 is intricately linked with NF-κB [16], a pivotal transcriptional regulator of stress-responsive genes, we postulate that NBCn1 functions as a key ion transporter whose expression and/or activity is modulated by NF-κB signaling during oxidative stress in lung cancer cells. The gene discussed is NFKB1; the disease is lung cancer.