KEAP1 and non-small cell lung carcinoma: Based on our results, a schematic model was proposed to describe the regulatory effects of S0859 on oxidative stress-mediated signaling, including the regulation of migratory module NBCn1 and oxidative stress defense genes in A549 NSCLC cells, which are a high level of NRF2 and Keap1 mutated cell line (Figure 7).