In α-synuclein preformed fibril-induced PD mouse models, melatonin signaling through the overexpression of the melatonin 1 receptor (MT1) prevented ferroptotic cell death by preserving the sirtuin 1/Nrf2/HO-1/GPX4 antioxidant axis and reducing the iron load and α-synuclein aggregation, unlike MT1 knockdown and knockout, which worsened neuronal loss [123]. Here, HMOX1 is linked to Parkinson disease.