Interestingly, the inhibition of glucocerebrosidase—encoded by the GBA1 gene, mutations of which are also a risk factor for developing PD—selectively impaired the ability of female microglia to enhance the Nrf2-dependent detoxification pathway in neurons, attenuating the sex differences typically observed in this neuroprotective function [118]. Here, NFE2L2 is linked to Parkinson disease.