MAPT and Alzheimer disease: In view of the fact that this molecule has already been linked to a reduction in hyperphosphorylated tau fibrils [97,98] and that its exogenous form can improve memory impairment and reduce AD-like hyperphosphorylation through its antioxidant function [99], melatonin as an inducer of the Nrf2 pathway should be further investigated as a potential treatment for familial tauopathies.