LRRK2 and Parkinson disease: Genetic mutations in key PD-linked genes, such as PRKN (Parkin), PINK1 (PINK1), LRRK2 (LRRK2), PARK7 (DJ-1), and SNCA (α-synuclein), contribute to familial forms of the disease and may disrupt the cell’s antioxidant responses [15].