Moreover, NOX4tecKO mice effectively downregulated neutrophil gelatinase-associated lipocalin (NGAL), a well-established biomarker for AKI, by 58% (from 2.4-fold to 1.0-fold relative to GAPDH; p < 0.0001) compared with NOX4fl/fl mice (Figure 1I,J). Here, LCN2 is linked to acute kidney injury.