Meanwhile, a recent study showed that PD patients with LID showed a significant reduction in antioxidant activity, together with an upregulation of inflammatory markers such as interleukin-1β (IL-1β), TOLLIP (a protein with a key role in inflammatory signaling, autophagy, and the transport of vacuoles within the cell), and C-reactive protein levels [56]. Here, IL1B is linked to Parkinson disease.